E131: A Sham-Controlled Sham of a Trial: RESET-RA

Today I cover the recent publication of the RESET-RA study, which evaluated vagal nerve stimulation to treat rheumatoid arthritis. Have a listen in full, but let me be clear upfront: I do not think this works and will not be referring any patients to receive it. This will forever be my pivotal example of the effect of unblinding, but would love to hear if you think different! 

 

Paper: https://www.nature.com/articles/s41591-025-04114-7

Supplement (see S4): https://www.nature.com/articles/s41591-025-04114-7#Sec27