5 Things That Go Up Your Butt for Better Health (and 3 That Shouldn’t): Colon Cancer, Gut Health & My Bad Microbiome Test

Colon cancer under 50, gut health, and the microbiome lead this solo episode of the Beautifully Broken Podcast, where Freddie Kimmel breaks down five things that go up your butt for better health, and three that shouldn't. Colorectal cancer is now the leading cause of cancer death in adults under 50, and half of those diagnoses are in people 45 to 49.

Freddie gets personal about his own objectively bad gut test, then walks through screening, butyrate, fecal microbiota transplant, rectal ozone, and pelvic floor and prostate therapy, with the studies behind each and an honest look at where the evidence stops. Long story long: find a guide, get screened, and test your poop.

In this episode:

- Cologuard vs. colonoscopy, and why screening at 45 matters

- The 2013 NEJM trial where FMT resolved recurrent C. diff in 15 of 16 patients

- How rectal ozone signals through Nrf2 and NF-kB, and where the FDA stands

- Stanford's pelvic floor trigger point protocol for chronic prostatitis

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Timestamps:

0:00 — Why we're talking about butt stuff2:04 — My gut test came back objectively bad3:22 — #1 Wipe or scope: colon cancer under 504:29 — 38 trillion bacteria, 30 trillion you6:24 — Antibiotics, glyphosate, low fiber, chronic stress8:26 — Colibactin and the Nature 2025 study9:08 — Cologuard vs. colonoscopy11:23 — What hospitals don't test + the Bristol stool chart12:40 — #2 Butyrate enemas and the 1992 colitis study15:59 — #3 FMT: the poop transplant17:38 — The 2013 NEJM C. diff trial19:37 — Bile acids, Rebyota and Vowst20:37 — Why the donor is everything23:36 — #4 Rectal ozone26:22 — Nrf2, NF-kB and oxidative "leg day"29:25 — #5 Pelvic floor and prostate massage31:31 — Chronic prostatitis and the UPOINT framework33:15 — Stanford's trigger point protocol35:57 — Didn't make the list: butthole sunning37:00 — Coffee enemas: against my own bias38:46 — Red light (no orifice needed)40:34 — My Tiny Health results and protocol44:16 — Shotgun metagenomics vs. GI-MAP, 16S and Viome46:41 — Find a clinician, don't skip screening

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For education only, not medical advice. Rectal therapies, FMT and ozone carry real risks. Work with a licensed clinician, and never skip recommended cancer screening.

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