Building the cult favorite skincare brand iS Clinical (and what the industry gets wrong.)

On this episode of The Treatment Room, I’m joined by Bryan Johns, co-founder, President and CEO of iS Clinical. Since founding iS Clinical with Alec Call in 2000, Bryan has been at the center of the professional skincare industry and the brand’s growth into a globally recognized name.

We also talk about Icon Skincare, the new prestige skincare brand Bryan and Alec launched in June 2026, and the inspiration behind its connection to Hollywood’s Golden Age and legendary facialist Madam Renna.

In this episode, we get into:

• How Bryan and Alec got their start in skincare and built the beloved celebrity brand.
• The story behind building iS Clinical
• What it really takes to start and develop a skincare line
• The surprising Marilyn Monroe connection behind Icon Skincare
• What Golden-Age Hollywood can teach us about skincare
• The role of estheticians and skincare professionals in the industry

• The complexity of formulation and why two products containing the same active ingredient aren't necessarily equivalent
• What actually goes into creating an effective skincare formula
• What decades of building iS Clinical taught him about skincare and business
• Why launch Icon after building one of the industry's most recognized professional skincare brands
• What's changed about launching a skincare company today
• Where Bryan thinks the skincare industry is headed next!

If you're an esthetician, skincare professional, brand founder, or just someone who loves skincare, this is a conversation you won't want to miss.

Listen to The Treatment Room wherever you get your podcasts.

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Learn more:iS ClinicalIcon Skincare

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