1 Dec 2025 10:00
December 2025: Adjunctive Lumateperone in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial
Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal.
- 00:48 Durgam interview
- 03:09 Mechanism of action
- 04:44 Patient-reported outcomes
- 06:31 Immediate clinical implications
- 07:32 Limitations
- 08:08 Further research
- 09:25 Kalin interview
- 09:38 Durgam et al.
- 13:09 Lin et al.
- 17:22 Brodsky et al.
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