FF 88 BICARICU-2, Bicarbonate in the ICU, still not helpful?

The Filtrate

Joel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)

Pedro Teixeira @nephcrit.bsky.social

Ana Gaddy @AnnaGaddy

Nayan Arora @captainchloride.bsky.social

Special Guests

David Goldfarb Professor of Medicene, NYU (COI)

Editing by

Pedro Teixeira

The Kidney Connection written and performed by Tim Yau

Show Notes

BICARBICU 2018 (Lancet)

BICARBICU-2 2025 (JAMA)

SOFA score (Wikipedia)

Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation (PubMed)

Effect of sodium bicarbonate on intracellular pH under different buffering conditions (PubMed)

Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC) (ICNARC Site)

SODium BICarbonate for Metabolic Acidosis in the ICU (SODa-BIC) (ClinicalTrials.gov)

Surviving Sepsis Campaign Guidelines 2021 (Website)

Tubular Secretions

Nayan: Louise Penny, The Black Wolf (&