Liver Imaging at a Turning Point

Dr. Linda Chu reviews four important advances in liver imaging, from standardized liver MR elastography to a novel contrast enhanced ultrasound biomarker and emerging combination therapies for hepatocellular carcinoma. She explores how the 19% rule for liver stiffness measurement, Perfusion Beyond Margin on ultrasound, and the evolving role of Y90 radioembolization with immunotherapy may improve disease monitoring, prognostication, and treatment strategies for patients with liver disease and liver cancer. Standardizing Liver MR Elastography: Guidelines for Reliable Stiffness Measurement in Chronic Liver Disease. Serai et al. Radiology 2026; 321(1):e260974. Perfusion beyond Margin in Hepatocellular Carcinoma: A Contrast-enhanced US Feature Related to Tumor Invasiveness and Prognosis. Ding and Ji et al. Radiology 2026; 321(1):e260918. Implications for Hepatocellular Carcinoma Ablation beyond the Tumor Margin: An Early Career Perspective. Shafaat and Reis. Radiology 2026; 321(1):e262757. Convergence of Local and Systemic Therapies: A Comprehensive Society of Interventional Oncology Framework for 90Y Radioembolization with Immunotherapy in HCC. Radiology 2026; 320(3):e251415.