The Holistic GLP-1 Podcast with Elizabeth McGann

20 Oct 2026 04:00

Your Brain on GLP-1 s (with Dr. Sasha High)

You know what you *should* be doing to improve your health. So why can it feel almost impossible to follow through?

What if the problem isn't a lack of willpower, but the biology of your brain?

In this fascinating conversation, Elizabeth welcomes **Dr. Sasha High**, a board-certified obesity medicine physician, internist, and founder of High Metabolic Clinic and Best Weight, to explore how GLP-1 medications influence the brain, quiet food noise, reduce cravings, and create new opportunities for lasting behavior change.

Discover why old habits can be so difficult to break, how cognitive behavioral therapy (CBT) and mindfulness can help interrupt self-defeating thought patterns, and why self-compassion may be one of the most powerful tools for sustainable weight management.

They also explore the hormonal and metabolic changes of menopause, the science of appetite regulation, and a liberating new perspective on obesity as a chronic medical condition rather than a failure of personal discipline.

If you've spent years knowing what to do but struggling to do it, this episode could change the way you understand yourself.

FREE MICRODOSING MASTERCLASS: https://go.elizabethmcgann.com/masterclass

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SHOW NOTES

(00:45) Why Knowing What to Do Isn't Enough

(04:15) The Science Behind Your Brain's Autopilot

(08:30) What GLP-1s Actually Do to Your Brain

(12:45) Can GLP-1s Help You Rewire Your Brain?

(17:00) How Long Does Lasting Habit Change Really Take?

(21:00) CBT and ACT: Powerful Tools for Changing Your Behavior

( 25:45 ) Your Thoughts Aren't Always Facts: How to Break Negative Thinking Patterns

(30:15) Breaking the Shame Cycle and Escaping the "Start Again Monday" Trap