4 Aug 2025 11:47
Episode 337: Deep Dive into Muscular Hypertrophy with Dr. Mike Roberts
On this episode of the Flex Diet Podcast, I chat with Dr. Mike Roberts, a full professor at Auburn University and head of the Nutri Bolt Applied and Molecular Physiology Lab. Mike’s one of the sharpest minds in muscle science, and we go deep into the nitty-gritty of hypertrophy, including everything from rodent studies to human trials to the molecular pathways that drive muscle growth.
We get into some serious geekery: ribosome biogenesis, muscle stem cells, the extracellular matrix — yeah, all the stuff happening behind the scenes when you train. Mike also shares his take on how HIIT and consistent resistance training impact muscle adaptation, and we riff on where nutrition fits into the equation.
If you're into the science of muscle or you're a coach looking to better understand the mechanisms behind hypertrophy, you’ll dig this one. Tons of actionable nuggets and some fascinating research.
Check it out!
Sponsors:
- Tecton Life Ketone drink! https://tectonlife.com/ DRMIKE to save 20%
- LMNT electrolyte drink mix: miketnelsonlmnt.com
- Beyond Power Voltra 1: https://miket.me/voltra1
Available now:
- Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.
Episode Chapters:
- 05:53 Dr. Mike Roberts' Academic Journey
- 07:21 Research Focus: Muscle Physiology and Aging
- 21:04 Innovative Research Projects and Findings
- 43:03 Exploring Pyro Sequencing and Methylation
- 45:17 Genetic Potential and Resistance Training
- 46:16 Extreme Responders and Genetic Research
- 47:21 Conference on Response Heterogeneity
- 50:16 Ribosome Biogenesis and Muscle Stem Cells
- 54:47 Extracellular Matrix and Hypertrophy
- 01:03:04 Eccentric Training and Muscle Growth
- 01:07:17 Practical Tips for Muscle Hypertrophy
- 01:16:58 Conclusion and Final Thoughts
Flex Diet Podcast Episodes You May Enjoy:
- Episode 161: Muscle hypertrophy, exercise selection, and nutrient timing, an interview with Dr Chester Soko - https://youtu.be/0snSfWTuVYQ
- Episode 328: Grit Gains: Building Mental Toughness and Resilience in Training with Ben Mayfield Smith - https://youtu.be/Kg77mu1MAIk
Connect with Mike:
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