Episode 95: Cytotoxic T Cells and Transcriptional Priming in Lung Transplantation

Today's JHLT: The Podcast features a recent article on a pediatric cohort in JHLT: "Cytotoxic CD8+ T cells persist and show transcriptional priming in lung transplantation."

Today's guest is senior author Don Hayes, Jr., MD, MS, Med, MBA, ISHLTF, of the Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine.

The discussion with Dr. Hayes explores:

• The fascinating behavior and persistence of CD8+ T-cell clones in the cohort
• What we know—and don't know—about these cells' role in inflammation and allograft rejection
• Therapeutic and clinical considerations for patients displaying these T-cells
• The future of the research, including further validation, surveillance, and precision immunosuppression

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.