FF 83 CONFIDENCE: Can We Start Flozins and Finerenone Simultaneously?

The Filtrate

Joel Topf @kidneyboy.bsky.social‬

Swapnil Hiremath @hswapnil.medsky.social

Nayan Arora captainchloride.bsky.social

Sopia Ambruso @sophia-kidney.bsky.social

Special Guests

Brendon Neuen @brendonneuen.bsky.social Associate Professor and Program Lead, Renal and Metabolic at The George Institute for Global Health. Nephrologist and Director of Kidney Trials at Royal North Shore Hospital.

Neuen has had three prior appearances on Freely Filtered: EMPA Kidney, DUPLEX and Sparsentan in FSGS, FLOW and Semaglutide

Muthiah Vaduganathan @mvaduganathan on X. Cardiologist at Brigham and Women's Hospital and Harvard Medical School. Assistant Professor of Medicine.

Editing by

Joel Topf

The Kidney Connection written and performed by Tim Yau

Show Notes

DONATE to NephJC!

Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes NEJM | NephJC Summary

FIDELIO Bakris et al, NEJM 2020 | NephJC Summary; subgroup throws doubt on efficacy of finerenone in patients on flozins

FIGARO Pitt et al, NEJM 2021; subgroups clearly shows finerenone works, flozins or not

NEJM editorial (wrongly) saying do not use Flozins unless on RASi 

Don’t use dual RAS blockade ONTARGET Yusuf et al, NEJM 2008; VA NEPHRON-D Fried et al NEJM 2013