FF95 The PUSH trial. Push it real good!

The Filtrate

Joel Topf@kidney_boy

Vipin Verghese@vipvargh.bsky.social

Nayan Arora @captainchloride

Special Guests

David Goldfarb Professor of Medicine, NYU (COI)

Megan Prochaska Assistant professor of medicine at University of Chicago

John Asplin Medical Director Consultant LithoLink (Twitter)

Editing

Anna Gaddy

The Kidney Connection written and performed by Timothy Yau

Show Notes

Kidney Treks, University of Chicago. For medical students.

The Push Trial: Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention NephJC Short | The Lancet

Charlie Pak trial showing increased urine volume reduced risk of kidney stones. Evidence justifying a high fluid intake in treatment of nephrolithiasis PubMed

The Borghi Trial: Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study PubMed

Medical Management of Kidney Stones: AUA Guideline (2026)

Weird little trial Asplin mentioned with amlodipine. But it was actually verapami. By Kemal Sarical: The effect of calcium channel blockers on stone regrowth and recurrence after shock wave lithotripsy PubMed

Borghi’s other giant study in kidney stones: Comparison of Two Diets for the Prevention of Recurrent Stones in Idiopathic Hypercalciuria NEJM

The No Stone Trial: Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence