Inside the Mind of the Mad Scientist Rewriting Aging : 1401

Your body does not fail all at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Theodore Achacoso and Boomer Anderson, leaders in Health Optimization Medicine and Practice. Dr. Achacoso is a physician-scientist and the founding pioneer of Health Optimization Medicine, known for his work on cellular networks, metabolomics, and mitochondrial function. Boomer Anderson is the CEO of Smarter Not Harder and Troscriptions, where he focuses on translating complex biology into practical tools for human performance and longevity.  

Together, they unpack how cells respond to perceived threats through the Cell Danger Response, why mitochondria control energy, inflammation, and repair, and why chasing disease labels misses the real drivers of aging. The discussion covers methylene blue as an electron recycler, why LDL cholesterol plays a role in detoxification and immune signaling, how fasting and ketosis shift metabolism between repair and growth, and why sleep optimization, circadian rhythm, and light exposure matter even more when you travel. They also explore neuroplasticity, consciousness, nootropics, supplements, and why health optimization works best when you restore balance instead of forcing outcomes. 

You’ll Learn: 

• What the Cell Danger Response is and how it reshapes aging and performance 

• How mitochondria sense stress before symptoms appear 

• Why cellular energy controls resilience, sleep, and longevity 

• How methylene blue supports mitochondrial electron flow 

• Why fasting and ketosis shift metabolism between repair and growth 

• How travel, light, and circadian disruption affect aging 

• Why very low LDL can impair detoxification and immune signaling 

• Why real anti-aging starts at the cellular level, not with disease labels 

Thank you to our sponsors! 

• AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. 
• Screenfit | Get your at-home eye training program for 40% off using code DAVE at www.screenfit.com/dave. 
• Puori | Use code DAVE at puori.com/DAVE to get 32% off your Puori Fish Oil when you start a subscription. You save more than $18. 
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, su