19 Jun 2026 02:00
This is Your Brain on Hormones
After reading something that said her menstrual cycle changes her brain each month, Senior Correspondent Molly Webster goes on a reporting mission to see if that’s true, and, if so, how.
This journey into sex hormones and the brain involves females and males, and exacting self-experimentation. It gets into PTSD, and ends with a new twist on self-care (hint: it’s biological). And, it starts to reveal a sneaky truth: that each one of us is at the mercy of a crashing sea of chemicals inside of us – those things we call hormones.
Special thanks to Emily Jacobs, Laura Pritschet, Pavel Shapturenka, and Dr. Catherine Woolley.EPISODE CREDITS: Hosted by - Molly Webster Reported by - Molly Webster Produced by - Mona Madgavkar with help from - Molly Webster Fact-checking by - Diane A. Kelly
EPISODE CITATIONS:
Articles - **The experiments we feature in this episode are called: 28andMe, 28andOC, and 28andHe, all of which took place at Emily Jacobs lab at the University of California, Santa Barbara.**
- The 28 Project (https://zpr.io/CSx6MnwZjRvp), background from the Jacobs lab
For more on how much variability there is between female and male animals, check out this “groundbreaking” study, referenced by Emily Jacobs in our episode
- Sex Bias in Neuroscience and Biomedical Research(https://zpr.io/ZRgKZzdNejUA), by Beery AK, Zucker I., Neurosci Biobehav Rev. 2011
Dr. Catherine Woolley has revolutionized the field of neuroscience and sex hormones, here’s more about her work …
- Sex Differences in the Brain Get Down to the Molecular Level Sex (https://zpr.io/UNCLE9J782N5), by Stephanie DeMarco, PhD, The Scientist.com
- Hormonal Effects on the Brain (https://zpr.io/DvNM9EkXdtGG), by Woolley, C.S. and Schwartzkroin, P.A. Epilepsia
Data sets -
Audio - In the episode, we mention Dr. Russ Poldrack and the Midnight Scan Club, as inspo for self-experimentation
- The Midnight Scan Club (https://zpr.io/CLBhNQSxK844), by Science Friday.
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