27 Oct 2026 09:00
Endo Uncovered Part 5: The Connection Between MCAS, Histamine & Endometriosis | Ep 431
What do mast cells, histamine, estrogen, and endometriosis all have in common? A whole lot more than you might think.
We're wrapping up the Endo Uncovered series with one of the most requested topics from Erin's Instagram community: the connection between mast cell activation syndrome (MCAS) and endometriosis.
In this episode, Erin and Rachel start with the basics (because what the heck is a mast cell, anyway?!) before getting into the very real connection between immune system dysregulation, histamine, estrogen, inflammation, and endometriosis symptoms, plus why MCAS can be so difficult to identify.
You’ll also hear a real client case study involving endometriosis, MCAS, mold exposure, elevated lead levels, gut dysbiosis, and methylation issues.
In this episode:
- What mast cells are, how they protect the body, and what happens when they keep releasing inflammatory chemicals
- The dangerous feedback loop that can amplify real physical symptoms
- What mold, heavy metals, chronic stress, infections, and histamine intake have to do with mast cell activation
- Why antihistamines can improve PMS and PMDD symptoms for some women
Resources mentioned:
Listen to Part 1, Part 2, Part 3, and Part 4 of the Endo Uncovered series.
Episode 429: How Your Nervous System Influences Your Health
Apply for 1:1 support here if you’re navigating painful periods, suspected or diagnosed endometriosis, gut symptoms, hormone issues, or inflammation.
Manifest Your Health is our neuroscience backed membership designed to help you reconnect with your body, regulate your nervous system, and finally break out of the symptom loop.
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FOR OUR FULL LIST OF LINKS + RESOURCES, HEAD TO:
https://www.thefunktionalnutritionist.com/podcast/431-endo-series-part-5
