26 Oct 2026 12:00
Ozone Therapy, EBOO & Major Autohemotherapy: What Actually Works with Micah Lowe
Ozone therapy, EBOO and Major Autohemotherapy: what the research supports, where the marketing outruns it, and how to build a smart ozone stack. SimplyO3 founder Micah Lowe returns for his fourth conversation with Freddie Kimmel on the Beautifully Broken Podcast.
Ozone works as a hormetic stressor, like exercise or sauna: a short oxidative hit that signals the NRF2 pathway and trains the body to build antioxidant capacity. Micah covers why ozone only works in a series, why he won't build EBOO equipment, ozonated glycerin, and the 1970s FDA statement that still shapes ozone in the US.
In this episode:
- How ozone triggers NRF2 and a hormetic antioxidant response
- EBOO vs. major autohemotherapy vs. rectal insufflation, and why direct IV is out
- Ozone's history from WWI to Velio Bocci, and the FDA's position
- Why diet, sleep and exercise still come first
Episode Highlights
0:00 — Micah Lowe returns
0:58 — Ozone, colon health and early-onset colorectal cancer
1:44 — What ozone is and why practitioners use it
2:28 — Coffee enemas: what the evidence shows
5:20 — Ozone as hormesis, like exercise
6:48 — The NRF2 pathway
8:13 — Oxidative stress and immune modulation
9:15 — Microcirculation and the VO2 max studies
12:14 — Freddie's ozone history since 2010
13:38 — How the ozone industry has changed
15:12 — Ozonated glycerin
22:20 — The 2020–2021 commercialization shift
26:58 — No free lunch: fundamentals first
29:34 — What EBOO is, and why Micah won't make it
33:28 — Why ozone works in a series
35:20 — Why direct IV ozone is condemned
37:02 — Micah's stack: MAH plus rectal insufflation
38:53 — Ozone history: Tesla, WWI and Bocci
43:09 — The FDA statement and the regulatory wall
49:10 — Who regulates clinics: state boards
51:38 — AI and slowing down to learn
59:06 — Where practitioners get trained
1:03:20 — Sauna and the home wellness toolkit
1:07:32 — Ozone as a home medicine cabinet
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Watch me Unbox the Simply 03 Ozone System
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For education only, not medical advice. Ozone therapy is not FDA-approved for any medical condition; talk with a licensed provider before starting any new therapy.
Big love, everybody.
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