The link between Histamine Intolerance and the Methylation Pathway with Zelda Graham

Why Women Are More Vulnerable—and What You Can Do Clinically

Could histamine intolerance be the hidden driver behind your patient’s anxiety, bloating, headaches, or skin flares? In this episode, nutritionist and epigenetics expert Zelda Graham breaks down the complex interplay between histamine, methylation dysfunction, gut health, and hormonal imbalances—especially in women.

You’ll gain critical insights into the role of DAO and HNMT enzymes, estrogen’s impact on histamine load, and why symptoms often worsen during ovulation and perimenopause.

Zelda also shares clinical strategies to identify and address root causes like mould exposure, gut dysbiosis, and methylation SNPS—plus targeted therapies using nutrients like quercetin, NAC, liposomal glutathione, and calcium D-glucarate.

This episode is essential listening for practitioners managing complex, multisystem female presentations—from hormone imbalances to unresolved histamine-related inflammation.

Connect with Zelda: 

Website: www.byronhealthandnutrition.com

Shownotes and references are available on the Designs for Health websiteRegister as a Designs for Health Practitioner and discover quality practitioner- only supplements at www.designsforhealth.com.au

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DISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health